神经丛蛋白B2抗体
规格：1mg/1ml
英文名： Plexin B2
别名： KIAA0315; Plexin B2; PlexinB2; Plexin-B2; MM1; PLXN B2; PLXNB2.
分子量： 203kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Plexin B
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞膜
神经丛蛋白B2抗体产品介绍：background: Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal神经丛蛋白B2抗体 root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met. Function: Plexin B2 is a transmembrane receptor for the class 4 semaphorin, SEMA4D. This receptor has key roles in RHOA activation and subsequent changes of the actin cytoskeleton, axon guidance, invasive growth 神经丛蛋白B2抗体and cell migration. Subunit: Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R. Subcellular Location: Membrane; single-pass type I membrane protein. Similarity: Belongs to the plexin family. Contains 3 IPT/TIG domains. Contains 1 Sema domain. Database links: UniProtKB/Swiss-Prot: O15031.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经丛蛋白B2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid