磷酸化异染色质蛋白1抗体
规格：1mg/1ml
英文名： phospho-heterochromatin protein 1(pTyr24)
别名： Antigen p25; Cbx 5; Cbx5; Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from Fruit
交叉反应：Fruit Fly,
细胞定位：
磷酸化异染色质蛋白1抗体产品介绍：background: HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small protein磷酸化异染色质蛋白1抗体s (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. Database links: GenBank: ACI96782.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 异染色质蛋白1（Heterochromatin protein 1 (HP1)）一般认为是异染色质的维持者，磷酸化异染色质蛋白1抗体异染色质是转录沉默的固缩DNA，常常与中心粒等区域有关。这种固缩的DNA被认为是转录因子无法接近的，但近期的Science上发表的两篇报道对这个观点提出了挑战。 这个新的研究提出HP1可能是异染色质活性调控的重要因子，在细胞生理活动中具有的重要功能。
磷酸化异染色质蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 染色质和核信号 昆虫
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid